Protein Details: Aquaporin-4

Protein ID

ICDB_Pro_0621

Protein Name

Aquaporin-4

Gene Name

Aqp4

Organism

Mus musculus (Mouse)

Length

323 amino acids

AlphaFoldDB

AF-P55088-F1-model_v4.pdb

Function

Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface . Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries;and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby;it is required for normal clearance of solutes from the brain interstitial fluid;including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability .

Sequence

MSDGAAARRWGKCGHSCSRESIMVAFKGVWTQAFWKAVSAEFLATLIFVLLGVGSTINWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCPDVELKRRLKEAFSKAAQQTKGSYMEVEDNRSQVETEDLILKPGVVHVIDIDRGEEKKGKDSSGEVLSSV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Brain edema; Infantile gastroenteritis; Encephalitis; Cerebral malaria; Schistosomiais

Location

Detected in brain cortex;especially around cortical blood vessels;and subjacent to pia;with lower levels in parenchymal membranes (PubMed:27751903). Detected in ependymal and astroglial cells in brain (PubMed:22896675;PubMed:27751903;PubMed:8660998;PubMed:9276712). Detected in supporting Hensens cells;inner sulcus cells and Claudius cells in the inner ear (PubMed:11406631). Detected in supporting Hensens cells;inner sulcus cells and Claudius cells in the inner ear (PubMed:11406631). Detected in supporting Hensens cells;inner sulcus cells and Claudius cells in the inner ear (PubMed:11406631). Detected in skeletal muscle (PubMed:29055082). Detected in gastric parietal cells (PubMed:10915655). Detected in principal cells in collecting ducts in kidney medulla (at protein level) (PubMed:16641094;PubMed:9276712). Detected in brain;heart and skeletal muscle (PubMed:8660998)...

DOI ID

10.1006/geno.1996.0214; 10.1006/geno.1997.4641; 10.1203/00006450-200009000-00012; 10.1101/gr.2596504; 10.1172/jci231; 10.1152/ajpgi.2000.279.2.g448; 10.1074/jbc.m104368200; 10.1073/pnas.0602087103; 10.1002/glia.20627; 10.1016/j.cell.2010.12.001; 10.1126/scitranslmed.3003748; 10.1016/j.mcn.2016.10.004; 10.7554/elife.40070; 10.1111/jcmm.13401; 10.1016/j.neuroimage.2018.12.026

RefSeq

NP_001295570.1 [P55088-2]; NP_001295571.1 [P55088-2]; NP_001295572.1 [P55088-2]; NP_001295573.1 [P55088-2]; NP_001295574.1 [P55088-2]; NP_001295575.1 [P55088-2]; NP_001295576.1 [P55088-2]; NP_001304658.1; NP_033830.2